Ppp1r13l-KO

Nomenclature

C57BL/6Smoc-Ppp1r13lem1Smoc

Cat. NO.

NM-KO-201327

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ppp1r13l

Synonyms

wa3， IASPP， Nkip1， AV260376

NCBI ID

333654

MGI ID

3525053

Ensembl ID

ENSMUSG00000040734

Pubmed

Ppp1r13l

Model Description

Exon 4-7 of Ppp1r13l gene was deleted to generate Ppp1r13l knockout mice.

Disease Connection

Arrhythmogenic Right Ventricular Cardiomyopathy

Phenotype(s)

MGI:5910392

Reference(s)

Notari M, Hu Y, Sutendra G, Dedeic Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X, iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81

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