Apc-Flox

Nomenclature

C57BL/6Smoc-Apctm2(flox)Smoc

Cat. NO.

NM-CKO-200013

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Apc

Synonyms

CC1， Min， mAPC， AI047805， AU020952， AW124434

NCBI ID

11789

MGI ID

88039

Ensembl ID

ENSMUSG00000005871

Pubmed

Apc

Human Ortholog

APC

Model Description

These mice carry loxP sites flanking exon 15 of Apc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Apc gene.
Research Application：Intestinal tumor research

Disease Connection

Colorectal Cancer

Phenotype(s)

MGI:5702414
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vil1-cre/ERT2 mice.

Reference(s)

Levy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M, Couty JP, Romagnolo B, Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nat Cell Biol. 2015 Aug;17(8):1062-73

Ovarian Cancer

Phenotype(s)

MGI:5779541
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Ad-Cre mice.

Reference(s)

Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR, Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 2007 Apr;11(4):321-33

ovarian cancer

Phenotype(s)

MGI:5583019
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pgr-Cre mice.

Reference(s)

van der Horst PH, van der Zee M, Heijmans-Antonissen C, Jia Y, DeMayo FJ, Lydon JP, van Deurzen CH, Ewing PC, Burger CW, Blok LJ, A mouse model for endometrioid ovarian cancer arising from the distal oviduct. Int J Cancer. 2014 Sep 1;135(5):1028-37

Pancreatic Mucinous Cystadenoma

Phenotype(s)

MGI:5898453
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with P53-Flox(2)(NM-CKO-190067) and Pdx1-cre mice.

Reference(s)

Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34

Familial Adenomatous Polyposis

Phenotype(s)

MGI:3590232
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lck-cre mice.

Reference(s)

Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K, Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82

Colorectal Cancer

Phenotype(s)

MGI:4456428
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fabp1-cre mice.

Reference(s)

Robanus-Maandag EC, Koelink PJ, Breukel C, Salvatori DC, Jagmohan-Changur SC, Bosch CA, Verspaget HW, Devilee P, Fodde R, Smits R, A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis. 2010 May;31(5):946-52

colorectal cancer

Phenotype(s)

MGI:3844311
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with CDX2-cre mice.

Reference(s)

Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER, Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res. 2007 Oct 15;67(20):9721-30

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