Pten-KO

Nomenclature

C57BL/6Smoc-Ptenem3Smoc

Cat. NO.

NM-KO-18002

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Pten

Synonyms

2310035O07Rik A130070J02Rik B430203M17Rik MMAC1 TEP1

NCBI ID

19211

MGI ID

109583

Ensembl ID

ENSMUSG00000013663

Pubmed

Pten

Human Ortholog

PTEN

Model Description

Exon5 of Pten gene was deleted to generate Pten knockout mice.
Research Application：cancer research

Disease Connection

Autism Spectrum Disorder

Phenotype(s)

MGI:5467729
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a4-KO(NM-KO-200892) mice.

Reference(s)

Page DT, Kuti OJ, Prestia C, Sur M, Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1989-94

Prostate Cancer

Phenotype(s)

MGI:5569926
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nkx3-1-KO(NM-KO-2112819) mice.

Reference(s)

Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C, Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2884-9

Autism Spectrum Disorder

Phenotype(s)

MGI:5805821

Reference(s)

Clipperton-Allen AE, Page DT, Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. Genes Brain Behav. 2015 Feb;14(2):145-57

Cowden Syndrome

Phenotype(s)

MGI:2179025

Reference(s)

Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP, Pten is essential for embryonic development and tumour suppression. Nat Genet. 1998 Aug;19(4):348-55

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