Zmpste24-KO

Nomenclature

C57BL/6Smoc-Zmpste24em1Smoc

Cat. NO.

NM-KO-18011

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Zmpste24

Synonyms

MADB; FACE1; STE24; Face-1; Ste24p; D030046F19; A530043O15Rik

NCBI ID

230709

MGI ID

1890508

Ensembl ID

ENSMUSG00000043207

Pubmed

Zmpste24

Human Ortholog

ZMPSTE24

Model Description

Exon4-6 of Zmpste24 gene were deleted to generate Zmpste24 knockout mice.
Research Application：premature aging disease Hutchinson-Gilford progeria syndrome (HGPS)

Disease Connection

Achalasia

Phenotype(s)

MGI:5754490
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lmna-KO(NM-K0-210380) mice.

Reference(s)

Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG, Mice that express farnesylated versions of prelamin A in neurons develop achalasia. Hum Mol Genet. 2015 May 15;24(10):2826-40

Familial Partial Lipodystrophy

Phenotype(s)

MGI:3621007

Reference(s)

Pendas AM, Zhou Z, Cadinanos J, Freije JM, Wang J, Hultenby K, Astudillo A, Wernerson A, Rodriguez F, Tryggvason K, Lopez-Otin C, Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet. 2002 May;31(1):94-9

Progeria

Phenotype(s)

MGI:3620907

Reference(s)

Fong LG, Ng JK, Meta M, Cote N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG, Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more