Ptpn11-Flox

Nomenclature

C57BL/6Smoc-Ptpn11em1(flox)Smoc

Cat. NO.

NM-CKO-231881

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Ptpn11

Synonyms

Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; AW536184; 2700084A17Rik

NCBI ID

19247

MGI ID

99511

Ensembl ID

ENSMUSG00000043733

Pubmed

Ptpn11

Human Ortholog

PTPN11

Model Description

These strains carry loxP sites flanking exon 4 of Ptpn11 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptpn11 gene.

Disease Connection

Juvenile Myelomonocytic Leukemia

Phenotype(s)

MGI:3845014
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mx1-cre mice.

Reference(s)

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG, Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood. 2009 Apr 30;113(18):4414-24

Noonan Syndrome 1

Phenotype(s)

MGI:6095197
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Emx1-Cre mice.

Reference(s)

Altmuller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernandez E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A, Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017 Mar;13(3):e1006684

Disease Of Metabolism

Phenotype(s)

MGI:5906203
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ckmm-cre mice.

Reference(s)

Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS, Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol. 2009 Jan;29(2):378-88

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