R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato
Nomenclature
C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
Cat. NO.
NM-KI-190010
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Gt(ROSA)26Sor
Model Description
A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.
Research Application：cancer
*Literature published using this strain should indicate: R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato mice (Cat. NO. NM-KI-190010) were purchased from Shanghai Model Organisms Center, Inc..
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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