Csf2-KO

Nomenclature

C57BL/6Smoc-Csf2em2Smoc

Cat. NO.

NM-KO-190532

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
CSF2

Synonyms

CSF; Csfgm; GMCSF; Gm-CSf; MGI-IGM

NCBI ID

12981

MGI ID

1339752

Ensembl ID

ENSMUSG00000018916

Pubmed

CSF2

Human Ortholog

CSF2

Model Description

Exon 1-3 of Csf2 gene was deleted to generate Csf2 knockout mice. Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality (Note from MGI).
Research Application：Growth Factors，NF-KB pathway，Allergy and Asthma，

Disease Connection

Systemic Lupus Erythematosus

Phenotype(s)

MGI:3586342
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Il3-KO(NM-KO-190498) mice.

Reference(s)

Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G, Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med. 2003 May 5;197(9):1213-9

Pulmonary Alveolar Proteinosis

Phenotype(s)

MGI:2652689

Reference(s)

Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JA, Maher DW, Cebon J, Sinickas V, Dunn AR, Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6

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