F9-KO(2)

Nomenclature

C57BL/6Smoc-F9em3Smoc

Cat. NO.

NM-KO-200607

Strain State

Repository Live

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Gene Summary

Gene Symbol
F9

Synonyms

Cf9; Cf-9; AW111646

NCBI ID

14071

MGI ID

88384

Ensembl ID

ENSMUSG00000031138

Pubmed

F9

Human Ortholog

F9

Model Description

F9-KO(2) mice (Stock No.NM-KO-200607）carry a knockout allele derived from the targeted deletion of exon 1-8. While F9-KO mice (Stock No.NM-KO-18046) carrying the exon 8 deletion.
Research Application：Hemophilia B

Disease Connection

hemophilia B

Phenotype(s)

MGI:2175873

Reference(s)

Wang L, Zoppe M, Hackeng TM, Griffin JH, Lee KF, Verma IM, A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11563-6

Validation Data

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Fig1. Detection of the blood coagulation index in F9-KO(2) mice.

(A) Activated partial thromboplastin time (APTT) assay showed that F9-KO(2) mice took significantly longer to clot than WT mice. 

(B) The results of fibrinogen(FIB) detection showed that there was no significant difference in FIB values between F9-KO(2) mice and WT mice.

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