Prex1-KO

Nomenclature

C57BL/6Smoc-Prex1em1Smoc

Cat. NO.

NM-KO-201823

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Prex1

Synonyms

Setd6， P-REX1， G630042G04

NCBI ID

277360

MGI ID

3040696

Ensembl ID

ENSMUSG00000039621

Pubmed

Prex1

Human Ortholog

PREX1

Model Description

Exon 6-7 of Prex1 gene was deleted to generate Prex1 knockout mice.

Disease Connection

Autism Spectrum Disorder

Phenotype(s)

MGI:3717173

Reference(s)

Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, Mei L, Lu L, Zhang C, Yue W, Xu L, Rao Y, Zhang D, Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6964-72

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