Scarb2-KO

Nomenclature

C57BL/6Smoc-Scarb2em1Smoc

Cat. NO.

NM-KO-201201

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Scarb2

Synonyms

LGP85， Cd36l2， LIMP-2， MLGP85， LIMP II， 9330185J12Rik

NCBI ID

12492

MGI ID

1196458

Ensembl ID

ENSMUSG00000029426

Pubmed

Scarb2

Human Ortholog

SCARB2

Model Description

Exon 2 of Scarb2 gene was deleted to generate Scarb2 knockout mice.

Disease Connection

Progressive Myoclonus Epilepsy

Phenotype(s)

MGI:5688743

Reference(s)

Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lullmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J, LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8

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