Sh2d1a-KO

Nomenclature

C57BL/6Smoc-Sh2d1aem1Smoc

Cat. NO.

NM-KO-200730

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Sh2d1a

Synonyms

SAP， Gm686

NCBI ID

20400

MGI ID

1328352

Ensembl ID

ENSMUSG00000005696

Pubmed

Sh2d1a

Human Ortholog

SH2D1A

Model Description

Exon 2 of Sh2d1a gene was deleted to generate Sh2d1a knockout mice.

Disease Connection

X-Linked Lymphoproliferative Syndrome 1

Phenotype(s)

MGI:3036915

Reference(s)

Czar MJ, Kersh EN, Mijares LA, Lanier G, Lewis J, Yap G, Chen A, Sher A, Duckett CS, Ahmed R, Schwartzberg PL, Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7449-54

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