Tnfrsf1a/Tnfrsf1b-KO

Nomenclature

C57BL/6Smoc-Tnfrsf1aem1Smoc Tnfrsf1aem1Smoc

Cat. NO.

NM-KO-18036

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
TNFRSF1B

Synonyms

p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

NCBI ID

21938

MGI ID

1314883

Ensembl ID

ENSMUSG00000028599

Pubmed

TNFRSF1B

Human Ortholog

TNFRSF1B

Gene Symbol
Tnfrsf1a

Synonyms

FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1

NCBI ID

21937

MGI ID

1314884

Ensembl ID

ENSMUSG00000030341

Pubmed

Tnfrsf1a

Human Ortholog

TNFRSF1A

Model Description

This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor).

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