Tlr4-KO

Nomenclature

C57BL/6Smoc-Tlr4em1Smoc

Cat. NO.

NM-KO-18052

Strain State

Repository Live

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Gene Summary

Gene Symbol
Tlr4

Synonyms

Lps; Ly87; Ran/M1; Rasl2-8

NCBI ID

21898

MGI ID

96824

Ensembl ID

ENSMUSG00000039005

Pubmed

Tlr4

Human Ortholog

TLR4

Model Description

This Tlr4 knockout mouse model was generated by knocking out the exon 2 region of the Tlr4 gene .
Research Application：Immune-related

Disease Connection

Pulmonary Emphysema

Phenotype(s)

MGI:3706992

Reference(s)

Zhang X, Shan P, Jiang G, Cohn L, Lee PJ, Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006 Nov;116(11):3050-9

Publications

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
References：Cell host & microbe

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