Trpv1-IRES-Cre

Nomenclature

C57BL/6Smoc-Trpv1em1(Myc-IRES-Cre)Smoc

Cat. NO.

NM-KI-200139

Strain State

Repository Live

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Gene Summary

Gene Symbol
Trpv1

Synonyms

Vr1; VR-1; OTRPC1; TRPV1beta; TRPV1alpha

NCBI ID

193034

MGI ID

1341787

Ensembl ID

ENSMUSG00000005952

Pubmed

Trpv1

Human Ortholog

TRPV1

Model Description

A Myc-IRES-Cre expression cassette was knocked into the Trpv1 gene stop codon site. Trpv1 is known as transient receptor potential cation channel, subfamily V, member 1. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying the pain caused by heat and capsaicin.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Trpv1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the dentate gyrus of Trpv1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  Trpv1Cre/+; Rosa26tdTomato/+ mice. Tdtomato is expressed in the brown fat, pancreas, kidney, retina, brain, pituitary gland, heart, lung, liver, stomach, salivary gland and skin. Tdtomato expression can also be observed in individual cells of the testis, epididymis, muscle, spleen, thymus, intestine and colon. (For more detailed information please contact our technical advisor.)


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