Tsc1-Flox

Nomenclature

C57BL/6Smoc-Tsc1tm1(flox)Smoc

Cat. NO.

NM-CKO-200231

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Tsc1

Synonyms

-

NCBI ID

64930

MGI ID

1929183

Ensembl ID

ENSMUSG00000026812

Pubmed

Tsc1

Human Ortholog

TSC1

Model Description

These mice carry loxP sites flanking exon 17-18 of Tsc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc1 gene.
Research Application：Research on mTOR signal transduction and respiratory electron transport, ATP synthesis produced by chemical permeation coupling, and heat produced by protein uncoupling

Disease Connection

Tuberous Sclerosis

Phenotype(s)

MGI:3802545
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Syn1-cre mice.

Reference(s)

Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ, Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci. 2008 May 21;28(21):5422-32

Autism Spectrum Disorder

Phenotype(s)

MGI:5641483
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pcp2-cre mice.

Reference(s)

Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M, Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012 Aug 30;488(7413):647-51

Tuberous Sclerosis

Phenotype(s)

MGI:3588988
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myl2-Cre mice.

Reference(s)

Meikle L, McMullen JR, Sherwood MC, Lader AS, Walker V, Chan JA, Kwiatkowski DJ, A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes. Hum Mol Genet. 2005 Feb 1;14(3):429-35

Anterior Segment Dysgenesis

Phenotype(s)

MGI:6295837
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lhx2-cre mice.

Reference(s)

Hagglund AC, Jones I, Carlsson L, A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development. Dis Model Mech. 2017 Mar 01;10(3):245-257

Tuberous Sclerosis

Phenotype(s)

MGI:3802584
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with GFAP-cre mice.

Reference(s)

Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M, Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiol Dis. 2007 Nov;28(2):184-96

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more