hPD-L1/hCTLA-4
Nomenclature
C57BL/6Smoc-Ctla4em1(hCTLA4)Cd274em1(hPD-L1)Smoc
Cat. NO.
NM-HU-00102
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
CTLA4
Gene Symbol
Cd274
Model Description
Validation Data
Fig1 Splenocytes from homozygous hPDL1/hCTLA4 mice were analyzed by flow cytometry after activation. mPDL1+ and mCTLA4+ were detectable in wild type (WT) C57BL/6, while hPDL1+ and hCTLA4+ cells were detectable in the homozygous hCTLA4/h4-1BB mice.
Fig2 hCTLA-4/PD-L1 mice+ MC38 cells efficacy studies. We have developed a CTLA-4/PD-L1 dKI humanized model and tested the combined treatment of Yervoy and Tecentriq, and then observed improved efficacy in the combination treatment.
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