hIL10

Nomenclature

C57BL/6Smoc-Il10tm4(hIL10)/Smoc

Cat. NO.

NM-HU-2000063

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Il10

Synonyms

CSIF; Il-10

NCBI ID

16153

MGI ID

96537

Ensembl ID

ENSMUSG00000016529

Pubmed

Il10

Human Ortholog

IL10

Model Description

The endogenous mouse Il10 gene was replaced by human IL10 gene.
Research Application：Cytokine humanization model；drug screening

Validation Data

image.png

Fig1. Detection of IL10 expression in bladder by RT-PCR. 

Wild type: only one band at 362 bp with primers F1/R1(mIl10);

Homozygous: only one band at 196 bp with primers F2/R2(hIL10).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of human and mouse IL10 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL10 and C57BL/6 mice were i.p. injected with LPS for 2h.



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