hPVRL2

Nomenclature

C57BL/6Smoc-Nectin2tm1(hNECTIN2)/Smoc

Cat. NO.

NM-HU-2000084

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Nectin2

Synonyms

MPH; Pvr; Pvs; Cd112; Pvrl2; AI325026; AI987993; nectin-2

NCBI ID

19294

MGI ID

97822

Ensembl ID

ENSMUSG00000062300

Pubmed

Nectin2

Human Ortholog

PVRL2

Model Description

The endogenous mouse Nectin2 gene was replaced by human PVRL2 gene.
Research Application：Immunotherapy,drug screening

Validation Data

image.png

Fig1. Detection of PVRL2 expression in duodenum and large Intestine by RT-PCR. 

Wild type: only one band at 342 bp with primers F1/R1 (mPvrl2);

Homozygous: only one band at 228 bp with primers F2/R2 (hPVRL2);

Abbr. M, DNA marker; HO, homozygous;  WT, wild type.

image.png

Fig2. Detection of human PVRL2 expression in duodenum and large Intestine in hPVRL2 KI mice. 

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Fig3. Detection of hPVRL2 expression on marcophages and dendritic cells in hPVRL2 KI mice.

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