hTIGIT/hPVR

Nomenclature

C57BL/6Smoc-Tigitem1(hTIGIT)Pvrem1(hPVR)Smoc

Cat. NO.

NM-HU-2000091

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
TIGIT

Synonyms

Vstm3

NCBI ID

100043314

MGI ID

3642260

Ensembl ID

ENSMUSG00000071552

Pubmed

TIGIT

Human Ortholog

TIGIT

Gene Symbol
PVR

Synonyms

PVS; mE4; HVED; Taa1; CD155; Tage4; necl-5; D7Ertd458e; 3830421F03Rik

NCBI ID

52118

MGI ID

107741

Ensembl ID

ENSMUSG00000040511

Pubmed

PVR

Human Ortholog

PVR

Model Description

These mice are obtained through breeding of two single gene humanized mice.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

TIGIT.png

Fig.1 Splenocytes from homozygous TIGIT&PVR mice were analyzed by flow cytometry after activation. mTIGIT+ cells were detectable in wild type (WT) C57BL/6, while hTIGIT+ cells were detectable in the homozygous TIGIT&PVR mice. 

PVR.png

Fig.2 Splenocytes from homozygous TIGIT&PVR mice were analyzed by flow cytometry after activation. mPVR+ cells were detectable in wild type (WT) C57BL/6, while hPVR + cells were detectable in the homozygous TIGIT&PVR mice.

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