hGPC3

Nomenclature

C57BL/6Smoc-Gpc3em1(hGPC3)Smoc

Cat. NO.

NM-HU-234374

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gpc3

Model Description

The endogenous mouse Gpc3 gene was replaced by human GPC3 gene.

Validation Data

image.png

Fig.1 Detection of GPC3 expression in kidney by RT-PCR. 

Wild type: only one band at 547 bp with primers F1/R1(mGpc3);

Heterozygous: one band at 547 bp with primers F1/R1(mGpc3) and one band at 219 bp with primers F2/R2(hGPC3). 

Abbr. M, DNA marker; HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human GPC3 expression in brain in hGPC3 mice by WB. 

Abbr. M, marker; WT, wild type; HE, heterozygous; PC, positive control, Hep G2 cells.


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