hTIGIT(BALB/c,3)

Nomenclature

C.B6-Tigittm3(hTIGIT)Smoc

Cat. NO.

NM-HU-234664

Strain State

Developing

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Gene Summary

Gene Symbol
TIGIT

Synonyms

Vstm3

NCBI ID

100043314

MGI ID

3642260

Ensembl ID

ENSMUSG00000071552

Pubmed

TIGIT

Human Ortholog

TIGIT

Model Description

The hTIGIT(3)(NM-HU-200244) mice were backcrossed to BALB/c genetic background, to create the new strain of hTIGIT(BALB/c,3)(NM-HU-234664) mice.

Validation Data

image.png

Fig.1 Detection of TIGIT expression in large intestine by RT-PCR. 

Wild type: only one band at 229 bp with primers F1/R1(mTigit);

Homozygous: only one band at 168 bp with primers F2/R2(hTIGIT).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of hTIGIT expression on CD8+ T cells in hTIGIT KI mice. 

Note. Splenocytes from BALB/c and homozygous hTIGIT mice were stimulated with ConA in vitro.

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