hPD-1/hCTLA-4(BALB/c)

Nomenclature

BALB/cAnSmoc-Pdcd1^em1(hPDCD1)Ctla4^{em1(hCTLA4)Smoc}

Cat. NO.

NM-HU-200277

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
CTLA4

Synonyms

Cd152; Ly-56; Ctla-4

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

CTLA4

Gene Symbol
Pdcd1

Synonyms

PD-1; Pdc1; Ly101

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

PDCD1

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Model Description

hPD-1(NM-HU-190079) was crossed with hCTLA4(2)(NM-HU-190078)to generate hPD-1/hCTLA4 mice

*Literature published using this strain should indicate: hPD-1/hCTLA-4(BALB/c) mice (Cat. NO. NM-HU-200277) were purchased from Shanghai Model Organisms Center, Inc..

Validation Data

Fig 1.In vivo efficacy study in PD1 & CTLA4 humanized mice. Keytruda, Opdico or Yervoy can inhibit the growth of CT26-hCD274 xenografts. The above data indicated that the hPD1/hCTLA4 humanized mouse is an effective model for antineoplastic drug screening.

hCTLA-4/hCCR8(BALB/c) Strain Name：BALB/cAnSmoc-Ccr8^em1(hCCR8)Ctla4^{em1(hCTLA4)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-220050
hCCR8/hCTLA-4 Strain Name：C57BL/6Smoc-Ccr8^em1(hCCR8)Ctla4^{em1(hCTLA4)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-210435
Mir31-KO(2) Strain Name：C57BL/6Smoc-Mir31^em2Smoc Strain State：Embryo cryopreservation \| Cat. NO.：NM-KO-210397
Ctla4-Flox Strain Name：C57BL/6Smoc-Ctla4^{em(flox)/Smoc} Strain State：Repository Live \| Cat. NO.：NM-CKO-230188
Ctla4-KO Strain Name：C57BL/6Smoc-Ctla4^em1Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-202037

U-GEMMs

Other Models

Models

hPD-1/hCTLA-4(BALB/c)

Gene Summary

Model Description

Validation Data

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U-GEMMs

Other Models

Models

hPD-1/hCTLA-4(BALB/c)

Gene Summary

Model Description

Validation Data

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