hPD-1/hCTLA-4
Nomenclature
C57BL/6Smoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Cat. NO.
NM-HU-00079
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
CTLA4
Gene Symbol
Pdcd1
Model Description
Validation Data
PD-1 expression in stimulated T cells
Fig1. The expression of human PD-1 and CTLA-4 in double humanized PD-1&CTLA-4 mice was confirmed by FACS.
Efficacy studies
Fig2. In vivo validation of double humanized PD-1&CTLA-4 mice. Double humanized mice were inoculated with MC38 cells, and randomly assigned to different groups (n=8) when the tumor grew to a volume of 100 mm3. A combinatorial treatment of anti-CTLA-4 and anti-PD-1 demonstrated a noticeable efficacy improvement compared to the same dose of single agent (top) without affecting the animal body weight (Bottom).
Re-challenge studies
Figure 3. As shown in the previous figure, animals of group 1-4 received different doses of either single agent or combinatorial treatment. This graph showed the progression of the tumor implanted in the cured, G4 mice, implicating a systematic anti-tumor effect induced by the combinatorial antibody treatment.
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreOur vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
Learn more
