Ncr1-IRES-DTRGFP

Nomenclature

C57BL/6Smoc-Ncr1em1(IRES-DTREGFP)Smoc

Cat. NO.

NM-KI-190044

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ncr1

Model Description

A IRES-DTREGFP expression cassette was knocked into the Ncr1 gene stop codon site.
Research Application:DTR mouse

Validation Data

Heterozygous Ncr1-IRES-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. After the tumors grew to 100 mm3, Ncr1-IRES-DTRGFP  mice were injected with Diphtheria toxin. 

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Fig1. The growth of MC38 tumors in Heterozygous Ncr1-IRES-DTRGFP mice and C57BL/6 mice. (Cooperation with CrownBio)

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Fig2. The percent of NK cell in peripheral blood of MC38 tumor-bearing Ncr1-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS.(Cooperation with CrownBio)

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Fig3. The percent of NK cell in peripheral blood of MC38 tumor-bearing Ncr1-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS.(Cooperation with CrownBio)


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