Knockout mouse model is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by deleting portions of the gene’s DNA sequence, or by replacing the gene with an altered DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important clues about the function of individual genes. Mice and humans share many genes in common. Hence, information from knockout mouse models can shed light on the biological roles of specific genes as well as on the involvement of those genes in human disease.
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Strain Name：C57BL/6Smoc-Agtr1Bem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190910
Research Application：Agtr1b/Agtr1a double gene function, blood pressure and kidney
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Strain Name：C57BL/6Smoc-Agtr2em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190911
Research Application：Angiotensin II response, pancreatitis, myocardial infarction; cardiovascular morphology and physiology, kidney and urine morphology and physiology; glucose and fat metabolism and balance; X-linked cognitive impairment
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Strain Name：C57BL/6Smoc-Agtrapem1Smoc
Strain State：Developing | Cat. NO.：TBD
Disease Connection：acquired metabolic disease
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Strain Name：C57BL/6Smoc-Agxtem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-210152
Disease Connection：primary hyperoxaluria type 1
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Strain Name：C57BL/6Smoc-Ahcyem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190238
Research Application：Immune-related
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Strain Name：C57BL/6Smoc-Ahnakem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190239
Research Application：Immune-related
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