Apela-KO(2)

Nomenclature

C57BL/6Smoc-Apelaem2Smoc

Cat. NO.

NM-KO-210328

Strain State

Repository Live

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Gene Summary

Gene Symbol

Synonyms

E， Ela， End， Ende， Elabela， Gm10664

NCBI ID

100038489

MGI ID

3642370

Ensembl ID

ENSMUSG00000079042

Pubmed

Human Ortholog

APELA

Model Description

Apela-KO(2) mice (Stock No.NM-KO-210328） carry a knockout allele derived from the targeted deletion of exon 3. While Apela-KO mice (Stock No.NM-KO-210268）carrying the exon 1-2 deletion.

Disease Connection

pre-eclampsia

Phenotype(s)

MGI:6118197

Reference(s)

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713

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