Adora2a-KO

Nomenclature

C57BL/6Smoc-Adora2aem1Smoc

Cat. NO.

NM-KO-200018

Strain State

Repository Live

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Gene Summary

Gene Symbol
Adora2a

Synonyms

A2aR; A2AAR; AA2AR

NCBI ID

11540

MGI ID

99402

Ensembl ID

ENSMUSG00000020178

Pubmed

Adora2a

Human Ortholog

ADORA2A

Model Description

Exon 3 of Adora2a gene was deleted to generate Adora2a knockout mice.
Research Application：Therapeutic antibody target

Disease Connection

Myopia

Phenotype(s)

MGI:3622794

Reference(s)

Zhou X, Huang Q, An J, Lu R, Qin X, Jiang L, Li Y, Wang J, Chen J, Qu J, Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4362-70

Primary Pulmonary Hypertension

Phenotype(s)

MGI:5473699

Reference(s)

Xu MH, Gong YS, Su MS, Dai ZY, Dai SS, Bao SZ, Li N, Zheng RY, He JC, Chen JF, Wang XT, Absence of the adenosine A2A receptor confers pulmonary arterial hypertension and increased pulmonary vascular remodeling in mice. J Vasc Res. 2011;48(2):171-83

Validation Data

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Fig1. Detection of Adora2a-ko expression in thymus and spleen by RT-PCR. Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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