Apc-KO

Nomenclature

C57BL/6Smoc-Apcem2Smoc

Cat. NO.

NM-KO-200612

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Apc

Synonyms

CC1， Min， mAPC， AI047805， AU020952， AW124434

NCBI ID

11789

MGI ID

88039

Ensembl ID

ENSMUSG00000005871

Pubmed

Apc

Human Ortholog

APC

Model Description

Exon 3 of APC gene was deleted to generate APC knockout mice.
Research Application：Cancer research

Disease Connection

colorectal cancer

Phenotype(s)

MGI:3513849

Reference(s)

Colnot S, Niwa-Kawakita M, Hamard G, Godard C, Le Plenier S, Houbron C, Romagnolo B, Berrebi D, Giovannini M, Perret C, Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest. 2004 Dec;84(12):1619-30

Familial Adenomatous Polyposis

Phenotype(s)

MGI:2175907

Reference(s)

Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M, Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4482-6

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