Hbb-bs/Hbb-bt-KO

Nomenclature

C57BL/6Smoc-Hbb-bsemHbb-btem1Smoc

Cat. NO.

NM-KO-234923

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Hbb-bt

Synonyms

Beta-t

NCBI ID

101488143

MGI ID

5474850

Ensembl ID

ENSMUSG00000073940

Pubmed

Hbb-bt

Human Ortholog

HBB-BT

Gene Symbol
Hbb-bs

Synonyms

Hbbt1; Hbbt2; Beta-s

NCBI ID

100503605

MGI ID

5474852

Ensembl ID

ENSMUSG00000052305

Pubmed

Hbb-bs

Human Ortholog

HBB-BS

Model Description

The 5' upstream sequence of Hbb-bs gene to the 3' downstream sequence of Hbb-bt gene were deleted to generate Hbb-bs and Hbb-bt knockout mouse.

Disease Connection

Beta thalassemia

Reference(s)

Zhang, F., Zhang, B., Wang, Y. et al. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature 622, 834–841 (2023). https://doi.org/10.1038/s41586-023-06611-6

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