R26-CAG-LSL-hIDH2*R140Q-IRES-Luc-2A-tdTomato

Nomenclature

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato)Smoc

Cat. NO.

NM-KI-190075

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Gt(ROSA)26Sor

Synonyms

R26，ROSA26，AV258896，Gtrgeo26，Gtrosa26，Thumpd3as1

NCBI ID

14910

MGI ID

104735

Ensembl ID

ENSMUSG00000086429

Pubmed

Gt(ROSA)26Sor

Model Description

These mice harbor a CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato cassette in the Rosa26 locus generated by homologous recombination.
Research Application：cancer research

Disease Connection

D-2-Hydroxyglutaric Aciduria

Phenotype(s)

MGI:5582197
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with ACTB-cre mice.

Reference(s)

Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG Jr, Bardeesy N, Wong KK, D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev. 2014 Mar 1;28(5):479-90

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