KPC(2)

Nomenclature

C57BL/6Smoc-Trp53tm7(R270H-flox)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc

Cat. NO.

NM-KI-220014

Strain State

Repository Live

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Gene Summary

Gene Symbol
Trp53

Synonyms

bbl; bfy; bhy; p44; p53; Tp53

NCBI ID

22059

MGI ID

98834

Ensembl ID

ENSMUSG00000059552

Pubmed

Trp53

Human Ortholog

TRP53

Gene Symbol
Kras

Synonyms

Ki-ras; K-ras; Kras2; Kras-2

NCBI ID

16653

MGI ID

96680

Ensembl ID

ENSMUSG00000030265

Pubmed

Kras

Human Ortholog

KRAS

Gene Symbol
pdx1

Synonyms

Ipf1， IDX-1， IPF-1， Mody4， STF-1， pdx-1

NCBI ID

18609

MGI ID

102851

Ensembl ID

ENSMUSG00000029644

Pubmed

pdx1

Model Description

Trp53-LSL-R270H, Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. While KPC mice function similarly to KPC(2) mice, for more detailed information please contact our technical advisor.
Research Application：Spontaneous pancreatic tumor

Disease Connection

pancreatic carcinoma

Reference(s)

Pancreatology . 2020 Jan;20(1):79-88. doi: 10.1016/j.pan.2019.11.006. Epub 2019 Nov 18.

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