Cdkn2C-KO

Nomenclature

C57BL/6Smoc-Cdkn2Cem1Smoc

Cat. NO.

NM-KO-2114003

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Cdkn2c

Synonyms

p18; INK4c; C77269; p18-INK6; p18INK4c; p18-INK4c

NCBI ID

12580

MGI ID

105388

Ensembl ID

ENSMUSG00000028551

Pubmed

Cdkn2c

Human Ortholog

CDKN2C

Model Description

Exon 3 of Cdkn2c gene was deleted to generate Cdkn2c knockout mice.

Disease Connection

Medulloblastoma

Phenotype(s)

MGI:3710320
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Trp53-KO(NM-KO-191203) mice.

Reference(s)

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF, The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15;19(22):2656-67

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