Tgfb2-KO

Nomenclature

C57BL/6Smoc-Tgfb2^em1Smoc

Cat. NO.

NM-KO-190548

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Tgfb2

Synonyms

Tgfb-2， BB105277， Tgf-beta2

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

TGFB2

Model Description

Exon 4 of Tgfb2 gene was deleted to generate Tgfb2 knockout mice.

Research Application：Cancer research related;Disease related

*Literature published using this strain should indicate: Tgfb2-KO mice (Cat. NO. NM-KO-190548) were purchased from Shanghai Model Organisms Center, Inc..

Disease Connection

Loeys-Dietz Syndrome

Phenotype(s)

MGI:5444484

Reference(s)

Lindsay ME, Schepers D, Bolar NA, Doyle JJ, Gallo E, Fert-Bober J, Kempers MJ, Fishman EK, Chen Y, Myers L, Bjeda D, Oswald G, Elias AF, Levy HP, Anderlid BM, Yang MH, Bongers EM, Timmermans J, Braverman AC, Canham N, Mortier GR, Brunner HG, Byers PH, Van Eyk J, Van Laer L, Dietz HC, Loeys BL, Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nat Genet. 2012 Aug;44(8):922-7

U-GEMMs

Other Models

Models

Tgfb2-KO

Gene Summary

Model Description

Disease Connection

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Tgfb2-KO(2) Strain Name：C57BL/6Smoc-Tgfb2^em²^Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-233006
Tgfb2-Flox Strain Name：C57BL/6Smoc-Tgfb2^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-2101370

U-GEMMs

Other Models

Models

Tgfb2-KO

Gene Summary

Model Description

Disease Connection

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