Txnip-KO(2)

Nomenclature

C57BL/6Smoc-Txnip^em1Smoc

Cat. NO.

NM-KO-190894

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Txnip

Synonyms

THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

TXNIP

Model Description

Using CRISPR/Cas9 technology,exon 2 of Txnip gene was deleted to generate Txnip knockout mice.

Research Application：Aging, Proteostasis, Immune system, NK cell development and activity, lipid metabolism, coagulation

*Literature published using this strain should indicate: Txnip-KO(2) mice (Cat. NO. NM-KO-190894) were purchased from Shanghai Model Organisms Center, Inc..

Disease Connection

Reye Syndrome

Phenotype(s)

MGI:3613200

Reference(s)

Oka S, et al., Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J. 2006 Jan;20(1):121-3

U-GEMMs

Other Models

Models

Txnip-KO(2)

Gene Summary

Model Description

Disease Connection

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Txnip-Flox Strain Name：C57BL/6Smoc-Txnip^{em1(flox)Smoc} Strain State：Developing \| Cat. NO.：TBD
Txnip-KO Strain Name：C57BL/6Smoc-Txnip^em1Smoc Strain State：Sperm cryopreservation \| Cat. NO.：NM-KO-200744

U-GEMMs

Other Models

Models

Txnip-KO(2)

Gene Summary

Model Description

Disease Connection

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