Calm1-KO
Nomenclature
C57BL/6Smoc-Calm1em1Smoc
Cat. NO.
NM-KO-190703
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Calm1
Model Description
Exon 2 of Calm1 gene was deleted to generate Calm1 knockout mice.
Research Application：The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14.
*Literature published using this strain should indicate: Calm1-KO mice (Cat. NO. NM-KO-190703) were purchased from Shanghai Model Organisms Center, Inc..
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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