Traf3ip2-KO

Nomenclature

C57BL/6Smoc-Traf3ip2em1Smoc

Cat. NO.

NM-KO-201221

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Traf3ip2

Synonyms

Act1， CIKS， AI429613

NCBI ID

103213

MGI ID

2143599

Ensembl ID

ENSMUSG00000019842

Pubmed

Traf3ip2

Human Ortholog

TRAF3IP2

Model Description

Exon 3 of Traf3ip2 gene was deleted to generate Traf3ip2 knockout mice.

Disease Connection

Sjogren's Syndrome

Phenotype(s)

MGI:5439184

Reference(s)

Qian Y, Giltiay N, Xiao J, Wang Y, Tian J, Han S, Scott M, Carter R, Jorgensen TN, Li X, Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren's syndrome. Eur J Immunol. 2008 Aug;38(8):2219-28

Systemic Lupus Erythematosus

Phenotype(s)

MGI:5440213

Reference(s)

Johnson AC, Davison LM, Giltiay NV, Vareechon C, Li X, Jorgensen TN, Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease. Eur J Immunol. 2012 Jul;42(7):1695-705

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