Aclidineleukin (high-dose IL-2) is the first FDA-approved cancer immunotherapy for metastatic renal cell carcinoma (RCC) and melanoma, but the widespread clinical use of aclidinein has been limited by its short half-life, serious side effects, and simultaneous stimulation of Treg activation. With the breakthrough of studies of immune checkpoint inhibitors, IL-2-based therapeutics has regained widespread attention, […]
CCR8, as a novel immune checkpoint in tumor microenvironment, was hotly discussed during 2022 AACR conference. Since then, numerous prestigious pharmaceutical corporations have shifted their attention to CCR8, previously almost unknown. You may wonder why CCR8 gave rise to so strong interest of pharmaceutical industry. Just follow us to have a quick review of CCR8, […]
Join our webinar on June 26th to explore the development and preclinical evaluation of Antibody-Drug Conjugates (ADCs), focusing on their components, mechanisms, and the selection of effective preclinical models for advancing targeted cancer therapies. Date: · Wednesday, June 26th, 2024; 2:00 pm EDT or 11:00 am PDT Webinar Highlights: Understand the components and mechanisms of […]
We provide gene editing techniques such as CRISPR/Cas9, transgenic approaches, or gene knockout strategies.
Researchers can request specific modifications to evaluate phenotypic changes, drug responses, or genetic interactions, facilitating the advancement of biomedical research and therapeutic developments.
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