Hexb-KO

Nomenclature

C57BL/6Smoc-Hexbem1Smoc

Cat. NO.

NM-KO-202069

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Hexb

Synonyms

NCBI ID

15212

MGI ID

96074

Ensembl ID

ENSMUSG00000021665

Pubmed

Hexb

Human Ortholog

HEXB

Model Description

Exon 2 of Hexb gene was deleted to generate Hexb knockout mice.

Disease Connection

Sly Syndrome

Phenotype(s)

MGI:2177551
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Hexa-KO(NM-KO-200986) mice.

Reference(s)

Sango K, McDonald MP, Crawley JN, Mack ML, Tifft CJ, Skop E, Starr CM, Hoffmann A, Sandhoff K, Suzuki K, Proia RL, Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis. Nat Genet. 1996 Nov;14(3):348-52

Sandhoff Disease

Phenotype(s)

MGI:3579384
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fcer1g-KO(NM-KO-190187) mice.

Reference(s)

Yamaguchi A, Katsuyama K, Nagahama K, Takai T, Aoki I, Yamanaka S, Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. J Clin Invest. 2004 Jan;113(2):200-8

Sandhoff disease

Phenotype(s)

MGI:3579804
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ccl3-KO(NM-KO-190014) mice.

Reference(s)

Wu YP, Proia RL, Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8425-30

Sandhoff disease

Phenotype(s)

MGI:2177468

Reference(s)

Sango K, Yamanaka S, Hoffmann A, Okuda Y, Grinberg A, Westphal H, McDonald MP, Crawley JN, Sandhoff K, Suzuki K, Proia RL, Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet. 1995 Oct;11(2):170-6

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more