Lep-KO

Nomenclature

B6;129S-Leptm1Smoc

Cat. NO.

NM-KO-00034

Strain State

Repository Live

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Gene Summary

Gene Symbol
Lep

Model Description

Exon 2 was replaced by Neo cassette.
Research Application:Insulin resistance,obesity,and type 2 diabetes etc.

Disease Connection

Abdominal Obesity-Metabolic Syndrome
Abdominal Obesity-Metabolic Syndrome 1
Non-Alcoholic Fatty Liver Disease
Obesity
Type 2 Diabetes Mellitus

Validation Data

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Fig1. Body weight and Blood glucose monitoring of ob/ob mice.

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Fig2. Evaluation of Oral glucose tolerance test (OGTT) of female ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. **, P ≤ 0.01.

Note. The tested ob/ob and C57BL/6 mice were 6 weeks old.

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Fig3. Detection of insulin levels in serum by ELISA. 

Abbr. Hom, homozygous; HE, heterozygous; WT, wild type.

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old.

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Fig4. H&E staining of the subcutaneous adipose tissue (SAT) in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 20.

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Fig5. Representative pictures of pancreas in ob/ob mice. 

These results suggested the inflammatory cell infiltration of the pancreas in ob/ob mice. 

Abbr. HO, homozygous; WT, wild type. 

Note. The tested ob/ob and C57BL/6 mice were 20 weeks old. Scale bar, 200 μm; magnification, × 10.


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