hFcRn(SD)
Nomenclature
SD-Fcgrtem1(hFCGRT)Smoc
Cat. NO.
NR-HU-200002
Strain State
Repository Live
Gene Summary
Model Description
Validation Data
Fig1. Expression characterization of hFCRN in hFCRN knockin rat by Western blot.
Abbr. HO, homozygous; WT, wild type.
Fig2. PK study of Keytruda in hFCRN rat.
Fig3. PK study of Cyramza in hFCRN rat.
Fig.4 Blood concentration curve of test articles in hFcRn/hALB dKI rats (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001).
In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party)
Fig.5 PK study of Keytruda in hALB/hFCRN dKl rat (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group)
Fig.6 PK study of Cyramza in hALB/hFCRN dKI rat(NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group)
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreOur vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
Learn more