Gja1-2A-DreERT2

Nomenclature

C57BL/6Smoc-Gja1em1(2A-DreERT2）Smoc

Cat. NO.

NM-KI-200026

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Gja1

Synonyms

Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43

NCBI ID

14609

MGI ID

95713

Ensembl ID

ENSMUSG00000050953

Pubmed

Gja1

Human Ortholog

GJA1

Model Description

A 2A-DreERT2 expression cassette was knocked into the Gja1 gene stop codon site via CRISPR/Cas9 mediated recombination.
Research Application：Dre recombinase tool

Validation Data

image.png

Fig.1 DreERT2-mediated recombination in the adipose tissue of Gja1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the adipose tissue after tamoxifen treatment. Connexin 43 (Cx43, encoded by Gja1, green) is a cell-cell communication gap junction protein expressed in adipose tissue. (Documented in the following reference.)


Publications

A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting
References：CELL STEM CELL

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more