Slc17a6-IRES-Cre

Nomenclature

C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200087

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Slc17a6

Model Description

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.
Research Application:Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Validation Data

image.png

Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)




You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more