Penk-IRES-Cre

Nomenclature

C57BL/6Smoc-Penk^{em1(IRES2-iCre)Smoc}

Cat. NO.

NM-KI-200088

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Penk

Synonyms

ENK; PPA; Penk1; AI326464

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

PENK

Model Description

A IRES2-iCre expression cassette was knocked into the Penk gene stop codon site.

Research Application：Penk gene encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. The gene product is involved in regulating synaptic plasticity, a crucial neurochemical mechanism underlying learning and memory.

*Literature published using this strain should indicate: Penk-IRES-Cre mice (Cat. NO. NM-KI-200088) were purchased from Shanghai Model Organisms Center, Inc..

Validation Data

NM-KI-200088 Penk-IRES-Cre-1.png

Fig. 1 Cre-mediated recombination in the brain of PenkCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of PenkCre/+; Rosa26tdTomato/+ mouse.

NM-KI-200088 Penk-IRES-Cre-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of PenkCre/+; Rosa26tdTomato/+ mice. Tdtomato is expressed throughout the brain. And cre-mediated recombination can be detected in some cells of the pituitary gland, kidney, intetstine, colon, retina, brown fat, testis, epididymis, salivary gland, stomach, thymus, lung, heart, liver and skin. (For more detailed information please contact our technical advisor.)

U-GEMMs

Other Models

Models

Penk-IRES-Cre

Gene Summary

Model Description

Validation Data

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Penk-Flox Strain Name：C57BL/6Smoc-Penk^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-210032

U-GEMMs

Other Models

Models

Penk-IRES-Cre

Gene Summary

Model Description

Validation Data

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