Pax7-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Pax7em1(IRES-Cre-ERT2)Smoc

Cat. NO.

NM-KI-200099

Strain State

Repository Live

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Gene Summary

Gene Symbol
Pax7

Synonyms

Pax-7

NCBI ID

18509

MGI ID

97491

Ensembl ID

ENSMUSG00000028736

Pubmed

Pax7

Human Ortholog

PAX7

Model Description

A IRES-Cre-ERT2 expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7 after tamoxifen treatment.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 CreERT2-mediated recombination in the muscle of Pax7CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle satellite cells of Pax7CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness were detected prior to tamoxifen exposure.

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Fig. 2 Detection of tdTomato(red) in various tissues of Pax7CreERT2/+; Rosa26tdTomato/+ mice. Tdtomato can not be detected in the brain, colon, eye, heart, intestine, kidney, lung, liver, pancreas, stomach, spleen, skin, salivary gland, testis or epididymis. (For more detailed information please contact our technical advisor.)


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