Isl1-Cre

Nomenclature

C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc

Cat. NO.

NM-KI-200126

Strain State

Sperm cryopreservation

Export PDF

Gene Summary

Gene Symbol
Isl1

Synonyms

-

NCBI ID

16392

MGI ID

101791

Ensembl ID

ENSMUSG00000042258

Pubmed

Isl1

Human Ortholog

ISL1

Model Description

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.
Research Application：Cre recombinase tool; Isl1-Cre mice express Cre recombinase under the control of the ISL1 transcription factor. It can be used for lineage tracing of Isl1 positive cells.

Validation Data

image.png

Fig. 1 Cre-mediated recombination in the retina of IslCreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer (RGC) and inner nuclear layer (INL) of IslCre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Cre-mediated recombination in the pancreas of IslCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar cells and islet cells derived from IslCre/+; Rosa26tdTomato/+ mouse.

image.png


Fig. 3 Detection of tdTomato(red) in various tissues of IslCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the retina, pancreas, heart, brain, pituitary gland, lung, liver, stomach, submandibular gland, brown fat, kidney, intestine, colon, spleen, thymus, testis and epididymis. (For more detailed information please contact our technical advisor.)


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more