Il17a-Cre

Nomenclature

C57BL/6Smoc-Il17a^{em1(iCre-polyA(SV40))Smoc}

Cat. NO.

NM-KI-200137

Strain State

Repository Live

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Gene Summary

Gene Symbol
IL17A

Synonyms

Il17; Ctla8; IL-17; Ctla-8; IL-17A

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

IL17A

Model Description

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.

Research Application：Cre recombinase tool; T helper cell

*Literature published using this strain should indicate: Il17a-Cre mice (Cat. NO. NM-KI-200137) were purchased from Shanghai Model Organisms Center, Inc..

Validation Data

Fig 1. Cre mediated recombination in lung of Il17aCre/+;Rosa26tdTomato/+ mouse.

Fig 2. Cre mediated recombination in mesenteric lymph nodes of Il17aCre/+;Rosa26tdTomato/+ mouse.

Il17a-Flox Strain Name：C57BL/6Smoc-Il17a^{em(flox)/Smoc} Strain State：Repository Live \| Cat. NO.：NM-CKO-230191
hIL17A Strain Name：C57BL/6Smoc-Il17a^t^{m1(hIL17A)/Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-HU-00042
Il17a-2A-CreERT2 Strain Name：C57BL/6Smoc-Il17a^{em1(2A-CreERT2)Smoc} Strain State：Embryo cryopreservation \| Cat. NO.：NM-KI-00059
Il17a-KO Strain Name：C57BL/6Smoc-IL17a^em1Smoc Strain State：Repository Live \| Cat. NO.：NM-KO-00131
hIL17A/hIL17F(DBA/1) Strain Name：DBA/1-Il17a^t^m1(hIL17A)Il17f^{em2(hIL17F)Smoc} Strain State：Developing \| Cat. NO.：NM-HU-240220

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Il17a-Cre

Gene Summary

Model Description

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