Opn4-Cre

Nomenclature

C57BL/6Smoc-Opn4em1(Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200304

Strain State

Repository Live

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Gene Summary

Gene Symbol
Opn4

Synonyms

Gm533; 1110007J02Rik

NCBI ID

30044

MGI ID

1353425

Ensembl ID

ENSMUSG00000021799

Pubmed

Opn4

Human Ortholog

OPN4

Model Description

Cre-WPRE-polyA expression cassette was knocked into the Opn4 gene start codon site. The melanopsin gene (Opn4) encodes a functional photopigment. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying circadian rhythm regulation.
Research Application：Cre recombinase tool; Circadian rhythm regulation

Validation Data

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Fig. 1 Cre-mediated recombination in the eyes of Opn4Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in retinal ganglion cell layer (RGC) and inner nuclear layer of Opn4Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  Opn4Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in   the eyes, hippocampus, olfactory bulb, serous layer of the large intestine, testis, epididymis, pulmonary bronchial epithelial cells, kidney, thymus and pituitary gland. Tdtomato expression can not be observed in the cerebellum, heart, liver, spleen, muscle, skin, stomach, small intestine or submandibular gland. (For more detailed information please contact our technical advisor.)


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