Oprk1-2A-Cre

Nomenclature

C57BL/6Smoc-Oprk1^{em1(2A-Cre)Smoc}

Cat. NO.

NM-KI-200299

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Oprk1

Synonyms

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

NCBI ID

MGI ID

Ensembl ID

Pubmed

Human Ortholog

OPRK1

Model Description

2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.

Research Application：Cre recombinase tool; Neuroscience

*Literature published using this strain should indicate: Oprk1-2A-Cre mice (Cat. NO. NM-KI-200299) were purchased from Shanghai Model Organisms Center, Inc..

Validation Data

Fig. 1 Cre-mediated recombination in the brain of Oprk1^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the brain of Oprk1^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Oprk1^Cre/+; Rosa26^tdTomato/+ mice. Tdtomato was also expressed in some cells of the liver, stomach, intestine, colon, muscle, eyes, heart, spleen and lung. Tdtomato expression can not be observed in the salivary gland, brown fat and skin.(For more detailed information please contact our technical advisor.)

U-GEMMs

Other Models

Models

Oprk1-2A-Cre

Gene Summary

Model Description

Validation Data

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Oprk1-Flox Strain Name：C57BL/6Smoc-Oprk1^{em1(flox)Smoc} Strain State：Sperm cryopreservation \| Cat. NO.：NM-CKO-200120
Oprk1-KO Strain Name：C57BL/6Smoc-Oprk1^em1Smoc Strain State：Embryo cryopreservation \| Cat. NO.：NM-KO-190642

U-GEMMs

Other Models

Models

Oprk1-2A-Cre

Gene Summary

Model Description

Validation Data

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