Strain Model Specification

hSIRPA/hCD47

Strain Name C57BL/6Smoc-Sirpaem1(hSIRPA)Cd47em1(hCD47)/Smoc
Catalog Number NM-HU-190019
Genetic Background C57BL/6Smoc
Gene Symbol Sirpa,Cd47
Synonyms Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, AI835480, IAP, Itgp
NCBI ID 19261, 16423, , , , , , , ↗
MGI ID 108563, 96617, , , , , , , ↗
Ensembl ID ENSMUSG00000037902, ENSMUSG00000055447, , , , , , , ↗
Strain State Not for sale
Research Application Immune-related

Validation Data

sirpa&cd47-tumor-volume.png

sirpa&cd47-body-weight.png

Fig1. Evaluation of human-specifc, CD47 antibody in the double humanized SIRPA&CD47 mice. The animals were inoculated with MC38 colon cancer cells, and randomly assigned into a control group and two treatment groups (n=6) when the tumors grew to 100 mm3. The humanized SIRPA&CD47 mice responded to human anti-CD47 (Left) without a significant body weight change at late time points (Right).