Knock-Out Mouse Models

Gain critical insights into genetic mechanisms with high-precision KO models. Our specialized solutions support functional discovery and clinical pathogenesis studies.

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Knockout Model Illustration

Functional Discovery

Uncover primary gene functions and biological pathways.

Disease Pathogenesis

Understand human disease mechanisms and prevention.

Drug Discovery

Streamline efficacy and toxicity screening pipelines.

Modification Technologies

CRISPR/Cas9 Method

  • Cycle: 4-6 months
  • Efficient production
  • High versatility
CRISPR Tech Diagram

ES Cell Targeting

  • Cycle: 7-12 months
  • Zero off-target risks
  • Complex modifications
ES Targeting Tech Diagram

Conventional Knock-Out

Osteoporosis Case Study

OPG knockout mice exhibit clear symptoms of osteoporosis, replicating human bone density disorders.

Conditional Knock-Out

Using the Cre-LoxP system for tissue-specific gene inactivation.

Parkinson's Disease Model

SLC39A14 mutation analysis localizing pathology.